Microscopic Menace — Scientists Discover Plastic Nanoparticles in Men's Testicles

The average person eats about 5 grams of plastic per week — about the amount found in one credit card.¹
So it’s no wonder that tiny pieces of plastic are turning up throughout the human body, including in places you might not expect. Following research that found plastic particles in the human bloodstream,² and another study that found them in the human heart,³ scientists have now discovered microplastics in men’s testicles.⁴

The study’s lead author, Dr. John Yu, a toxicologist in the College of Nursing at the University of New Mexico, wasn’t expecting microplastics to have infiltrated the testicles, given the tight blood-tissue barrier in the male reproductive system, known as the blood-testis barrier.

As noted in Pharmacological Reviews, “The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian body.”⁵ The presence of microplastics in the testes suggests that microplastics can bypass or penetrate the BTB, raising concerns about their ability to infiltrate other protected and sensitive tissues in the body, as well as their potential impact on reproductive health.

Microplastics Found in Human and Dog Testicles

For the study, researchers from the University of New Mexico measured 12 types of microplastics in 47 canine and 23 human testes.⁶ Microplastics are small plastic particles that are less than 5 millimeters in size. They may be intentionally manufactured for use in products like cosmetics, personal care items (such as exfoliating beads in face scrubs) and industrial applications. They also include microfibers shed from synthetic clothing during washing.

Microplastics also include small plastic fragments that result from the breakdown of larger plastic items, such as bottles, bags and other plastic debris. This breakdown can occur due to environmental exposure, such as sunlight (photodegradation), ocean waves and weathering.

The study involved both human and dog testicles, as dogs share many physiological and anatomical similarities with humans, making them a valuable model for studying human diseases and conditions.

Further, because dogs share the same living environment as humans, they are exposed to similar pollutants, chemicals and other potential hazards. As such, they’re often considered sentinel animals,⁷ meaning they can serve as early warning indicators of potential health risks and environmental hazards that might also affect humans.

The study found microplastics in all the canine and human testes examined, with significant differences between individuals. On average, total microplastic levels were 122.63 µg (micrograms) per gram (g) in dogs and 328.44 µg/g in humans.⁸ Both humans and canines had similar proportions of the main types of microplastics, with polyethylene (PE) being the most common.

Polyvinyl chloride (PVC) was also detected and linked with lower sperm count in dog testicles. Higher levels of PVC were also associated with decreased weight of the testicles, as was polyethylene terephthalate (PET).⁹ A 2023 study similarly found microplastics in the male reproductive system, including the testis and semen.¹⁰

Are Microplastics Involved in Male Infertility?

It’s estimated that 11 million tons of plastic waste enter the world’s oceans annually — an amount that could nearly triple by 2040.¹¹ What’s the end result of a plastic world? An impending fertility crisis is upon us. Men experienced a 50% to 60% decline in sperm counts from 1973 to 2011, according to a 2017 study published in Human Reproduction Update.¹²

An update to the study, which includes data from 53 countries and an additional seven years¹³ — 2011 to 2018 — found sperm concentration declined “appreciably” by 51.6% from 1973 to 2018. The percent decline per year doubled, increasing from 1.16% after 1972 to 2.64% after 2000.¹⁴

Total sperm count also declined at an alarming level — 62.3% from 1973 to 2018. A class of plastic chemicals called phthalates, which are so ubiquitous that the U.S. Centers for Disease Control and Prevention has stated “phthalate exposure is widespread in the U.S. population,”¹⁵ may be particularly to blame.

An estimated 8.4 million metric tons of plasticizers, including phthalates, are used worldwide each year,¹⁶ with phthalate production amounting to about 4.9 million metric tons annually.¹⁷ Microplastics often contain phthalates, which can leach out of the material¹⁸ causing endocrine-disrupting effects.

Exposure to Plastic Chemicals in Utero May Affect Male Fertility as an Adult

Women’s exposure to phthalates during pregnancy is linked to male babies’ anogenital distance (AGD) — the distance from the anus to the base of the penis — with higher exposure associated with shortened AGD.¹⁹ Later in life, shorter AGD is linked with a smaller penis²⁰ and poorer semen quality, such that AGD at birth may be predictive of adult reproductive function.²¹

Phthalate syndrome refers to a number of disturbances to male reproductive development that have been observed after exposure to phthalates in utero.²² In studies on rats, it’s been found that when a rat that’s been gestating in a mother rat fed phthalates during the sensitive periods of reproduction, his genitals end up smaller and less developed, his testicles might not be fully descended, his penis may be smaller, and the whole size of the genital area is smaller.^23,24

What’s more, phthalates represent only one class of endocrine-disrupting chemicals. There are many more, including bisphenol-A (BPA), flame retardants, pesticides and per- and polyfluoroalkyl chemicals (PFAS) chemicals.²⁵ Since microplastics often contain harmful endocrine-disrupting chemicals, this is one way they may affect fertility.

It’s also likely that they affect fertility via other mechanisms as well, including inflammation, oxidative stress and even direct disruption of reproductive functions if they accumulate in the testes and other sensitive areas.

An evidence review conducted for California State Legislature in 2023 revealed, in fact, that “exposure to microplastics is suspected to adversely impact sperm quality and testicular health in humans based on … high quality of the body of evidence.”²⁶

Plastic’s Estrogenic Effects

Plastics are xenoestrogens that can mimic the effects of estrogen in the body.²⁷ Much of their danger is related to their stimulation of estrogen receptors. Phthalates, for instance, have estrogenic properties, and some endocrine-disrupting chemicals are also considered estrogenic carcinogens.

This is because the abnormal stimulation of estrogen receptors promotes cell proliferation and potentially contributes to the development and progression of estrogen-sensitive cancers, such as breast cancer²⁸ and endometrial cancer.²⁹

Due to their estrogenic effects, plastics exposure contributes to estrogen dominance, which may affect men’s reproductive health. Exposure to certain endocrine disruptors is associated with reduced semen quality and impaired fertility in men,³⁰ for instance, while endocrine disruptors — particularly xenoestrogens — are also “etiologic factors in the global decrease of sperm counts and other problems of the male reproductive tract.”³¹

Progesterone Can Help Lower Your Estrogen Burden

Before you consider using progesterone it is important to understand that it is not a magic bullet and you get the most benefit by implementing a Bioenergetic diet approach that allows you to effectively burn glucose as your primary fuel with backing up electrons in your mitochondria that reduces your energy production. My new book coming out shortly about Cellular Health covers this process in great detail.

Once you have dialed in your diet, an effective strategy that can help counteract estrogen excess is to take transmucosal progesterone (not oral or transdermal), which is a natural estrogen antagonist. Progesterone is one of only four hormones I believe many adults can benefit from. (The other three are thyroid hormone T3, DHEA and pregnenolone.)

I do not recommend transdermal progesterone, as your skin expresses high levels of 5-alpha reductase enzyme, which causes a significant portion of the progesterone you’re taking to be irreversibly converted primarily into allopregnanolone and cannot be converted back into progesterone.

Ideal Way to Administer Progesterone

Please note that when progesterone is used transmucosally on your gums as I advise, the FDA believes that somehow converts it into a drug and prohibits any company from advising that on its label.

However, please understand that it is perfectly legal for any physician to recommend an off-label indication for a drug to their patient. In this case progesterone is a natural hormone and not a drug and is very safe even in high doses. This is unlike synthetic progesterone called progestins that are used by drug companies, but frequently, and incorrectly, referred.

Dr. Ray Peat has done the seminal work in progesterone and probably was the world’s greatest expert on progesterone. He wrote his Ph.D. on estrogen in 1982 and spent most of his professional career documenting the need to counteract the dangers of excess estrogen with low LA diets and transmucosal progesterone supplementation.

He determined that most solvents do not dissolve progesterone well and discovered that vitamin E is the best solvent to optimally provide progesterone in your tissue. Vitamin E also protects you against damage from LA. You just need to be very careful about which vitamin E you use as most supplemental vitamin E on the market is worse than worthless and will cause you harm not benefit.

It is imperative to avoid using any synthetic vitamin E (alpha tocopherol acetate — the acetate indicates that it’s synthetic). Natural vitamin E will be labeled “d alpha tocopherol.” This is the pure D isomer, which is what your body can use. There are also other vitamin E isomers, and you want the complete spectrum of tocopherols and tocotrienols, specifically the beta, gamma, and delta types, in the effective D isomer.

There are also other vitamin E isomers, and you want the complete spectrum of tocopherols and tocotrienols, specifically the beta, gamma, and delta types, in the effective D isomer. As an example of an ideal vitamin E you can look at the label on our vitamin E in our store. You can use any brand that has a similar label.

You can purchase pharmaceutical grade bioidentical progesterone as Progesterone Powder, Bioidentical Micronized Powder, 10 Grams for about $40 on many online stores like Amazon. That is nearly a year’s supply, depending on the dose you choose.

However, you will need to purchase some small stainless steel measuring spoons as you will need a 1/64 tsp which is 25 mg and a 1/32 tsp which is 50 mg. A normal dose is typically 25-50 mg and is taken 30 minutes before bed as it has an anti-cortisol function and will increase GABA levels for a good night’s sleep.

Unfortunately, this vendor frequently runs out of product, and if that’s the case, then you can use Simply Progesterone by Health Natura. It’s premixed with vitamin E and MCT oil.

If you are a menstruating woman, you should take the progesterone during the luteal phase or the last half of your cycle, which can be determined by starting 10 days after the first day of your period and stopping the progesterone when your period starts.

If you are a male or non-menstruating woman you can take the progesterone every day for four to six months and then cycle off for one week. The best time of day to take progesterone is 30 minutes before bed as it has an anti-cortisol function and will increase GABA levels for a good night’s sleep.

This is what I have personally doing for over a year with very good results. I am a physician so do not have any problems doing this. If you aren’t a physician you should consult one before using this therapy, as transmucosal progesterone therapy requires a doctor’s prescription.

Additional Strategies to Decrease Your Estrogen Load

Considering that estrogenic microplastics are ubiquitous in the environment, including in food and drinking water, taking steps to avoid them is important both for reproductive and overall health — and may help lower your estrogen burden.

You can help reduce your exposure by becoming conscious of the plastic you’re using daily — and cut back where you can. Some steps are easy, like swapping plastic bags, bottles, straws, utensils and food containers for more durable, reusable options. You’ll also want to choose fresh foods as much as possible. Avoid fast foods and ultraprocessed foods, and choose those with minimal natural packaging or glass packaging instead.

You should also filter your drinking water and be mindful of the materials you use in your home. Avoid flooring, shower curtains and furniture made with phthalates, and vacuum often to pick up household dust, which is often contaminated. Some additional commonsense strategies that can help you limit your exposure and lower your estrogen load include: